Chocolate May Ease
Migraines According
To New Study
Migraines According
To New Study
Dietary Supplements of Cocoa May Repress Inflammatory
Responses In The Brain linked To Migraines, Suggest Results
From a New Study.
Results from an animal study indicated that consuming a diet enriched with 10 percent cocoa increased levels of anti-inflammatory compounds in the brain as well as repressing levels of pro-inflammatory processes, scientists from Missouri State University have reported at the International Headache Society's (IHS) 14th International Headache Congress in Philadelphia.
"To our knowledge, this is first evidence for the use of cocoa as a dietary supplement to cause an up regulation of (anti-inflammatory proteins and cytokines) as well as repress expression of acute and chronic inflammatory responses within trigeminal ganglia," state the researchers in their conference abstract. The trigeminal ganglia which are thought to play a role in migraine.
"Importantly, our data also provide evidence that cocoa contains biologically active compounds that could be beneficial in the treatment of trigeminal-mediated diseases of the head and face."
Migraine Statistics
About 12 - 15 per cent of people in the United Kingdom, (nine million people), suffer from migraines, with twice as many women as men affected by the complaint. In the United States, about 36 million people suffer with it,more than eitherdiabetes or asthma, according to the HIS.
The headaches are sometimes preceded by flashes of light, blind spots,tingling in the arms or legs, or anxiety. Suffers generally experience a pounding sensation in one side of the head and many undergo nausea, vomiting, and extreme sensitivity to light and noise. The symptoms are often severe and debilitating, lasting anywhere between four and 72 hours.
"So much more research is needed in understanding this devastating disease that robs millions of Americans of a productive quality of life."
Controlled Laboratory Study...
The researchers fed laboratory subjects a control diet or isocaloric diets enriched with 1 or 10 per cent cocoa for 14 days. After two weeks of feeding, the subjects were given an injection of capsaicin to produce an acute inflammatory response, or complete Freund's adjuvant (CFA), which produces a chronic inflammatory response.
The subjects fed the control diet and injected with capsaicin or CFA expressed higher levels of the inflammatory proteins MAP kinases (MAPK), while supplementation with cocoa was found to suppress these increases, report the researchers.
Additionally, those fed cocoa-enriched diets were found to have increased levels of the anti-inflammatory proteins MAP k inase phosphatases (MKP), compared to the subjects on the control diet. The cocoa-fed subjectss also have higher levels of the anti-inflammatory molecule IL-10 in their neurons.
"Cocoa enriched diets are able to repress the stimulated expression of proteins associated with the promotion and maintenance of inflammatory responses," concluded the researchers.
Source... International Headache Society's 14th International Headache Congress "Repression of acute and chronic inflammatory changes in trigeminal ganglion neurons and glia in response to cocoa enriched diets"
Responses In The Brain linked To Migraines, Suggest Results
From a New Study.
Results from an animal study indicated that consuming a diet enriched with 10 percent cocoa increased levels of anti-inflammatory compounds in the brain as well as repressing levels of pro-inflammatory processes, scientists from Missouri State University have reported at the International Headache Society's (IHS) 14th International Headache Congress in Philadelphia.
"To our knowledge, this is first evidence for the use of cocoa as a dietary supplement to cause an up regulation of (anti-inflammatory proteins and cytokines) as well as repress expression of acute and chronic inflammatory responses within trigeminal ganglia," state the researchers in their conference abstract. The trigeminal ganglia which are thought to play a role in migraine.
"Importantly, our data also provide evidence that cocoa contains biologically active compounds that could be beneficial in the treatment of trigeminal-mediated diseases of the head and face."
Migraine Statistics
About 12 - 15 per cent of people in the United Kingdom, (nine million people), suffer from migraines, with twice as many women as men affected by the complaint. In the United States, about 36 million people suffer with it,more than eitherdiabetes or asthma, according to the HIS.
The headaches are sometimes preceded by flashes of light, blind spots,tingling in the arms or legs, or anxiety. Suffers generally experience a pounding sensation in one side of the head and many undergo nausea, vomiting, and extreme sensitivity to light and noise. The symptoms are often severe and debilitating, lasting anywhere between four and 72 hours.
"So much more research is needed in understanding this devastating disease that robs millions of Americans of a productive quality of life."
Controlled Laboratory Study...
The researchers fed laboratory subjects a control diet or isocaloric diets enriched with 1 or 10 per cent cocoa for 14 days. After two weeks of feeding, the subjects were given an injection of capsaicin to produce an acute inflammatory response, or complete Freund's adjuvant (CFA), which produces a chronic inflammatory response.
The subjects fed the control diet and injected with capsaicin or CFA expressed higher levels of the inflammatory proteins MAP kinases (MAPK), while supplementation with cocoa was found to suppress these increases, report the researchers.
Additionally, those fed cocoa-enriched diets were found to have increased levels of the anti-inflammatory proteins MAP k inase phosphatases (MKP), compared to the subjects on the control diet. The cocoa-fed subjectss also have higher levels of the anti-inflammatory molecule IL-10 in their neurons.
"Cocoa enriched diets are able to repress the stimulated expression of proteins associated with the promotion and maintenance of inflammatory responses," concluded the researchers.
Source... International Headache Society's 14th International Headache Congress "Repression of acute and chronic inflammatory changes in trigeminal ganglion neurons and glia in response to cocoa enriched diets"
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